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AngioPlus® Core
Coronary Physiology Assessment System

Product Introduction

An innovative angiography-based coronary physiology technology developed in China. Requires only single-or dual-view coronary angiography. No pressure wire or hyperemic agents required. Rapidly calculates μFR to assess myocardial ischemia.

Key Features

*μFR in China branded as QFR or μQFR

Clinical Benefits

  • 01

    Precisely assess ischemia-causing lesions to guide treatment decisions

  • 02

    Precisely assess complex lesions and optimize procedural strategy

  • 03

    Plan virtually before PCI and precisely verify treatment results after PCI

  • 04

    Assess the microcirculation without additional procedural steps

  • 05

    Assess plaque stability from angiography and predict future risk

Angiography-derived fractional flow reserve versus coronary angiography to guide coronary artery bypass grafting in patients undergoing surgical valve procedures with concomitant coronary artery disea

Zhu Y, Cheng Z, Zhao Y, et al. Lancet. 2026;407:1161-1170. doi:10.1016/S0140-6736(25)02418-3

The FAVOR IV-QVAS trial demonstrates that in patients undergoing valve surgery with concomitant CAD, μFR-guided CABG reduces perioperative events versus anatomical guidance, without increasing adverse cardiovascular events at a median 27-month follow-up.

Complete Revascularization Guided by Functional Coronary Angiography in STEMI

Biscaglia S, Erriquez A, Colaiori I, et al. N Engl J Med. 2026. doi:10.1056/NEJMoa2605373

The AIR-STEMI trial (n=1823) demonstrates that in STEMI patients with multivessel disease, μFR-guided complete revascularization reduces major adverse events by 38% (8.9% vs 13.7%, P<0.001), while also reducing contrast-associated kidney injury and major bleeding.

Radial wall strain for residual risk stratification after percutaneous coronary intervention

Huang J, Tu S, Huang H, et al. EuroIntervention. 2026;22:e978-e989. doi:10.4244/EIJ-D-26-00126

The TARGET All Comers study shows that angiography-derived RWS independently predicts long-term adverse events in non-target vessels after PCI (HR 4.82), with the highest predictive accuracy for non-target vessel revascularization (AUC 0.92).

Prognostic Impact of Quantitative Flow Ratio-Derived Physiology for Intermediate Non-Infarct-Related Artery in Acute Myocardial Infarction

Tsunamoto H, Otake H, et al. Heart Vessels. 2026. doi:10.1007/s00380-025-02650-3

μFR-derived physiological indices identify high-risk intermediate non-infarct-related artery lesions in AMI patients, guiding treatment decisions and improving long-term outcomes.

VERMONT μQFR: Diagnostic Accuracy of Murray Law-Based 2D-μQFR Compared to 3D-μQFR and vFFR

Akrawi D, Kadappu K, Xu J, et al. Catheter Cardiovasc Interv. 2026. doi:10.1002/ccd.70768

The VERMONT study confirms excellent 2D-μFR diagnostic accuracy (AUC 0.95, sensitivity 93%, specificity 92%), with analysis time 15 minutes faster than invasive FFR and good inter-observer agreement.

Angiography-derived fractional flow reserve versus intravascular ultrasound to guide percutaneous coronary intervention in patients with coronary artery disease (FLAVOUR II): a multicentre, randomised

Hu X, Zhang J, Yang S, et al. Lancet. 2025. doi:10.1016/S0140-6736(25)00504-5

The FLAVOUR II trial demonstrates that μFR-guided PCI is non-inferior to IVUS guidance for 12-month clinical outcomes, with fewer stents implanted, offering a more cost-effective choice for patients with intermediate stenosis.

Angiography-Derived Microcirculatory Resistance in Detecting Microvascular Obstruction and Predicting Heart Failure After STEMI

Lu G, et al. Circ Cardiovasc Imaging. 2025;18:e017506. doi:10.1161/CIRCIMAGING.124.017506

Angiography-derived AMR detects microvascular obstruction after STEMI and predicts heart failure, enabling microcirculatory functional assessment without additional procedures.

Prognostic Implications of Angiographically Derived Coronary Radial Wall Strain in Diabetic Patients and Non–Flow-Limiting Stenosis

Wang Z, Kedhi E, Liu X, et al. JACC Cardiovasc Interv. 2025;18(10):1232-1242. doi:10.1016/j.jcin.2025.02.009

The COMBINE OCT-FFR study shows that RWS predicts adverse events in diabetic patients with non-flow-limiting lesions (HR 2.70), independently of and incrementally to OCT-derived vulnerable plaque features, enabling angiographic plaque stability assessment.

Single-view angiographic microcirculatory resistance index after primary PCI: the EARLY-MYO-AMR study

Zhang Z, Ding S, Guo Q, et al. EuroIntervention. 2025;21:e1015-e1027. doi:10.4244/EIJ-D-24-00952

The EARLY-MYO-AMR study confirms that post-PPCI AMR >26.6 predicts microvascular dysfunction (AUC 0.721) and independently predicts long-term MACE, offering a pressure wire-free microcirculatory assessment tool for STEMI patients.

Prognostic Value of Postpercutaneous Coronary Intervention Murray-Law-Based Quantitative Flow Ratio: Post Hoc Analysis From FLAVOUR Trial

Ding D, Zhang J, Koo BK, Tu S, et al. JACC: Asia. 2025;1:59-70.

A post hoc analysis of the FLAVOUR trial shows that post-PCI μFR has independent prognostic value, optimizing post-procedural physiological assessment and long-term patient management.

Three-Year Clinical Impact of Murray Law-Based Quantitative Flow Ratio and OCT- or FFR-Guidance in Angiographically Intermediate Coronary Lesions

Aurigemma C, Ding D, Burzotta F, et al. Circ Cardiovasc Interv. 2024;17(5):e013191. doi:10.1161/CIRCINTERVENTIONS.123.013191

Three-year clinical outcomes of μFR-guided treatment of intermediate lesions are comparable to OCT/FFR guidance, while reducing invasive procedures and medical costs, making it suitable for routine clinical use.

Prognostic Value of Murray Law-Based QFR (μQFR)-Guided Virtual PCI in Patients With Physiological Ischemia

Chen L, Tu S, Luo Y, et al. Circ Cardiovasc Interv. 2024;17(10):e014362. doi:10.1161/CIRCINTERVENTIONS.124.014362

μFR virtual PCI guidance improves outcomes in patients with physiological ischemia, enabling pre-procedural precision planning and post-procedural efficacy validation to optimize interventional strategies.

Coronary Physiology Guidance vs Conventional Angiography for Optimization of Percutaneous Coronary Intervention: The AQVA-II Trial

Biscaglia S, Verardi FM, Erriquez A, et al. JACC Cardiovasc Interv. 2024;17(2):277-287. doi:10.1016/j.jcin.2023.10.032

The AQVA-II trial demonstrates that in CHIP patients, physiology-guided PCI achieved optimal post-PCI FFR (>0.86) more frequently than conventional angiography (77% vs 54%, P<0.0001), with angiography-derived FFR noninferior to microcatheter-derived FFR.

Left main bifurcation stenting: impact of residual ischaemia on cardiovascular mortality

Wang HY, Zhang R, Dou K, et al. Eur Heart J. 2023;44(41):4324-4336. doi:10.1093/eurheartj/ehad318

Residual ischemia detected by μFR after left main bifurcation stenting was present in 13.2% of patients, with significantly higher cardiovascular mortality, indicating that post-procedural physiological assessment identifies high-risk patients with "anatomical but not physiological success," guiding post-PCI optimization.

The Association Between Angiographically Derived Radial Wall Strain and the Risk of Acute Myocardial Infarction

Li C, Wang Z, Yang H, et al. JACC Cardiovasc Interv. 2023;16(9):1039-1049. doi:10.1016/j.jcin.2023.02.012

This study confirms that high-strain patterns on angiography-derived RWS are associated with increased future AMI risk in mild-to-moderate lesions (AUC 0.83), identifying vulnerable plaques from routine angiography and predicting long-term event risk.

Radial wall strain: a novel angiographic measure of plaque composition and vulnerability

Hong H, Li C, Gutiérrez-Chico JL, et al. EuroIntervention. 2022;18:1001-1010.

Angiography-derived RWS assesses plaque composition and vulnerability, correlating significantly with OCT lipid plaque features, enabling non-invasive plaque stability assessment and risk stratification.

Radial wall strain assessment from AI-assisted angiography: feasibility and agreement with OCT as reference standard

Huang J, Tu S, Li C, et al. J Soc Cardiovasc Angiogr Interv. 2023;2:100570. doi:10.1016/j.jscai.2022.100570

AI-assisted angiographic RWS assessment is feasible with good agreement with OCT vulnerable plaque features, enabling routine clinical use and automated plaque stability evaluation.

Short-Term Risk Stratification of Non–Flow-Limiting Coronary Stenosis by Angiographically Derived Radial Wall Strain

Tu S, et al. J Am Coll Cardiol. 2023;81:756-767. doi:10.1016/j.jacc.2022.11.056

Angiography-derived RWS provides short-term risk stratification for non-flow-limiting stenosis; RWS ≥13% identifies vulnerable plaques, predicts long-term event risk, and guides intensive therapy (FAVOR III China RWS).

Two birds with one stone: integrated assessment of coronary physiology and plaque vulnerability from a single angiographic view- a case report

Fezzi S, et al. Eur Heart J Case Rep. 2023;7:ytad309. doi:10.1093/ehjcr/ytad309

Single-view angiography simultaneously assesses μFR physiology and RWS plaque vulnerability, enabling one-stop functional plus structural dual-dimensional assessment to optimize clinical decision-making.

Feasibility of Quantitative Flow Ratio Virtual Stenting for Guidance of Serial Coronary Lesions Intervention

Guan S, Gan Q, Han W, et al. J Am Heart Assoc. 2022. doi:10.1161/JAHA.122.025663

This study confirms that μFR virtual stenting accurately identifies the main flow-limiting lesion in serial disease, guiding staged interventional strategies. It correlates strongly with FFR (r=0.97), enabling pre-procedural virtual planning.

Quantitative Flow Ratio Based on Murray Fractal Law: Accuracy of Single Versus Two Angiographic Views

Tu S, et al. J Soc Cardiovasc Angiogr Interv. 2022;1:100399. doi:10.1016/j.jscai.2022.100399

Single-view μFR has comparable diagnostic accuracy to two-view μFR, simplifying the workflow and improving clinical efficiency, making it suitable for emergency and complex lesion scenarios.

In Vivo Validation of a Novel Computational Approach to Assess Microcirculatory Resistance Based on a Single Angiographic View

Fan Y, Fezzi S, Sun P, et al. J Pers Med. 2022;12(11):1798. doi:10.3390/jpm12111798

Single-view angiographic AMR shows good correlation with invasive IMR (r=0.83) and diagnostic accuracy AUC 0.94, enabling non-invasive microcirculatory functional assessment.

Diagnostic accuracy of quantitative flow ratio for assessment of coronary stenosis significance from a single angiographic view: A novel method based on bifurcation fractal law

Tu S, Ding D, Chang Y, Li C, Wijns W, Xu B. Catheter Cardiovasc Interv. 2021;97:1040-1047. doi:10.1002/ccd.29592

Single-view μFR based on Murray's fractal law demonstrates excellent diagnostic accuracy and high feasibility, identifying hemodynamically significant stenoses without the need for a pressure wire.

Angiographic quantitative flow ratio-guided coronary intervention (FAVOR III China): a multicentre, randomised, sham-controlled trial

Xu B, Tu S, Song L, et al. Lancet. 2021;398:2149-2159. doi:10.1016/S0140-6736(21)02248-0

The FAVOR III China trial (n=3847) confirms that μFR-guided PCI significantly reduces 1-year major adverse events by 35%, reduces unnecessary stent implantation, and alleviates patient burden while controlling healthcare costs.

Diagnostic Accuracy of Angiography-Based Quantitative Flow Ratio Measurements for Online Assessment of Coronary Stenosis

Xu B, Tu S, Qiao S, et al. J Am Coll Cardiol. 2017;70(25):3077-3087. doi:10.1016/j.jacc.2017.10.035

The FAVOR II China study (n=308) confirms μFR diagnostic accuracy of 92.4%, significantly exceeding the pre-specified target, validating the clinical feasibility of μFR without pressure wires or hyperemic agents.