Key Publications
The history of computational coronary physiology
FAVOR III China (RCT):
Tu S, Song L, et al, FAVOR III China study group. Angiographic quantitative flow ratio-guided coronary intervention (FAVOR III China): a multicentre, randomised, sham-controlled trial. Lancet. 2021 Nov 3;S0140-6736(21)02248-0. doi: 10.1016/S0140-6736(21)02248-0.
Song L, Tu S, Sun Z, Wang Y, Ding D, Guan C, et al. Quantitative flow ratio-guided strategy versus angiography-guided strategy for percutaneous coronary intervention: Rationale and design of the FAVOR III China trial. Am Heart J, Inpress, Available online 24 February 2020.
Reviews of angiography-based QFR
Tu S, Westra J, Adjedj J, Ding D, Liang F, Holm N. R., Reiber H, Wijins W. Fractional Flow Reserve in clinical practice: from wire-based invasive measurement to image-based computation. European Heart Journal. 2020 Sep 7;41(34):3271-3279.doi: 10.1093/eurheartj/ehz918.
Ding D, Huang J, Westra J, Cohen DJ, Chen Y, Andersen BK, Holm NR, Tu S, Wijns W. Immediate post-procedural functional assessment of percutaneous coronary intervention: current evidence and future directions. European Heart Journal. 2021 Apr 5:ehab186. doi: 10.1093/eurheartj/ehab186.
QFR FAVOR II China:
Tu S, Qiao S, Qu X, Chen Y, Yang J, Guo L, Sun Z, Li Z, Tian F, Fang W, Chen J, Li W, Guan C, Holm NR, Wijns W, Hu S. Angiography-Based Quantitative Flow Ratio for Online Assessment of Coronary Stenosis: FAVOR II China Study. J Am Coll Cardiol. 2017 Dec 26;70(25):3077-3087. doi:10.1016/j.jacc.2017.10.035.
QFR FAVOR II Europe-Japan:
Westra J, Andersen BK, Campo G, Matsuo H, Koltowski L, Eftekhari A, Liu T, Serafino LD, Girolamo DD, Escaned J, Nef H, Naber C, Barbierato M, Tu S, Neghabat O, Madsen M, Tebaldi M, Tanigaki T, Kochman J, Somi S, Esposito G, Mercone G, Mejia-Renteria H, Ronco F, Bøtker HE, Wijns W, Christiansen EH, Holm NR. Diagnostic Performance of In-Procedure Angiography-Derived Quantitative Flow Reserve Compared to Pressure-Derived Fractional Flow Reserve: The FAVOR II Europe-Japan Study. J AM HEART ASSOC. 2018;7: e009603. DOI: 10.1161/JAHA.118.009603.
QFR FAVOR Pilot:
Tu S, Westra J, Yang J, von Birgelen C, Ferrara A, Pellicano M, Nef H, Tebaldi M, Murasato Y, Lansky A, Barbato E, van der Heijden LC, Reiber JH, Holm NR, Wijns W; FAVOR Pilot Trial Study Group. Diagnostic Accuracy of Fast Computational Approaches to Derive Fractional Flow ReserveFrom Diagnostic Coronary Angiography: The International Multicenter FAVOR Pilot Study. JACC Cardiovasc Interv. 2016 Oct 10;9(19):2024-2035. doi: 10.1016/j.jcin.2016.07.013.
First UFR validation study:
Yu W , Tanigaki T, Ding D, Wu P , Du H , Ling L; Huang B , Li G , Yan W , Zhang S , Yan F, Okubo M, Matsuo H , Wijns W, Tu S. Accuracy of intravascular ultrasound-based fractional flow reserve in identifying hemodynamic significance of coronary stenosis Circulation. Circ Cardiovasc Interv. 2021 Feb;14(2):e009840. doi: 10.1161/CIRCINTERVENTIONS.120.009840. Epub 2021 Feb 5. PMID: 33541105
First OFR validation study:
Yu W, Huang H, Jia D, Chen S, Raffel OC, Ding D, Tian F, Kan J, Zhang S, Yan Y, Chen Y, Bezerra HG, Wijns W, Tu S. Diagnostic Accuracy of Intracoronary Optical Coherence Tomography-derived Fractional Flow Reserve for Assessment of Coronary Stenosis Severity. EuroIntervention. 2019 Jun 20;15(2):189-197. doi: 10.4244/EIJ-D-19-00182.
First CT-QFR validation study:
Li Z, Zhang J, Xu L, Yang W, Li G, Ding D, Chang Y, Yu M, Kitslaar P, Zhang S, Reiber JHC, Arbab-Zadeh A, Yan F, Tu S. Diagnostic Accuracy of a Fast Computational Approach to Derive Fractional Flow Reserve From Coronary CT Angiography. JACC Cardiovasc Imaging. 2019 Sep 12. pii: S1936-878X(19)30728-4. doi: 10.1016/j.jcmg.2019.08.003.
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